COVID-19 and its treatments: lights and shadows on testicular functionReview Published on 2023-02-012023-07-10 Journal: Endocrine [Category] COVID19(2023년), [키워드] Andrological health COVID-19 cytokine male fertility SARS-CoV-2 spermatogenesis. [DOI] 10.1007/s12020-022-03221-6 PMC 바로가기 [Article Type] Review
Synthetic Stimulator of Interferon Genes (STING) Agonists Induce a Cytokine-Mediated Anti-Hepatitis B Virus Response in Nonparenchymal Liver CellsArticle Published on 2023-01-132023-06-11 Journal: ACS Infectious Diseases [Category] B형 간염, [키워드] antiviral immunity Chronic Hepatitis B cytokine HBV-persistent mouse model nonparenchymal liver cells. STING [DOI] 10.1021/acsinfecdis.2c00424 PMC 바로가기
The role of cytokines and their antagonists in the treatment of COVID-19 patientsReview Published on 2023-01-012023-07-09 Journal: Reviews in Medical Virology [Category] COVID19(2023년), [키워드] COVID-19 cytokine SARS-CoV-2 tocilizumab. [DOI] 10.1002/rmv.2372 PMC 바로가기 [Article Type] Review
COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesisArticle Published on 2022-12-192023-07-10 Journal: Brain : a journal of neurology [Category] COVID19(2023년), [키워드] Brain COVID-19 cytokine neurogenesis. SARS-CoV-2 [DOI] 10.1093/brain/awac270 PMC 바로가기
Interleukin-18 and COVID-19Original Paper Published on 2022-12-162022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval Analysis applied association conducted Coronavirus Disease (COVID)-19 COVID-19 cytokine estimate Evolutionary biology experimental design Exploratory analysis Genetic Genome-wide association study genome-wide significant hospitalised IFN Immunity interferon interferon gamma Interleukin-18 investigated less liberal lower risk Mendelian randomisation Odds ratio precursor predicted predictor predictors Prevent randomisation severe COVID-19 severity Standard deviation vulnerability was related with COVID-19 [DOI] 10.1017/S0950268821002636 PMC 바로가기 [Article Type] Original Paper
Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing Transcriptome sequencing. transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
COVID-19: imbalanced cell-mediated immune response drives to immunopathologyArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome alveolar damage Antiviral caused cell-mediated immune cell-mediated immune response changes in consequence coronavirus coronavirus disease COVID-19 Critical cytokine Cytokine storm effective Endotheliitis exacerbated excessive inflammation fluid overload homeostasis Host host cells immune immune responses immune system Immunological response immunopathology Inflammatory response Invasion involved lung damage Lung injury manifested mechanism NETs neutrophil activation organs pandemic Pathogenesis pathogenesis. pathophysiological progression SARS-CoV-2 SARS-CoV-2-specific immune responses severe disease syndrome therapeutic agent Therapeutic strategies tissue Trigger viral infection [DOI] 10.1080/22221751.2022.2122579 PMC 바로가기
Combining intramuscular and intranasal homologous prime-boost with a chimpanzee adenovirus-based COVID-19 vaccine elicits potent humoral and cellular immune responses in mice근육내 및 비강내 상동 프라임-부스트를 침팬지 아데노바이러스 기반 COVID-19 백신과 결합하면 마우스에서 강력한 체액성 및 세포성 면역 반응을 이끌어냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Adenovirus adenovirus-based Adenovirus-vectored vaccine Administered antibody titres approach BALB/c mice booster Cellular immune response ChAdTS-S coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines cytokine decrease Efficacy elicit elicited evaluated followed by group highest homologous humoral IFN-γ IFN-γ ELISPOT IgA IgG immune immune responses immunogenicity intracellular cytokine staining intramuscular intramuscular vaccination intranasal intranasal. Meso Scale Discovery mice prime immunization priming protocol provide pseudovirus neutralizing antibody respiratory responsible SARS-CoV-2 serotype shown T-cell Response T-cell responses tested titre vaccination Vaccine variants vectored vaccine [DOI] 10.1080/22221751.2022.2097479 PMC 바로가기 [Article Type] Article
Molecular and pro-inflammatory aspects of COVID-19: The impact on cardiometabolic healthArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 진단, [키워드] affected cardiometabolic cardiovascular Cluster Complication country COVID COVID-19 COVID-19 pandemic COVID-19 severity CVD cytokine cytokine production diabetes Final hallmark Health hypertension IL-6 IL10 IL2 IL4 IL8 immune system increased the risk infected patient Inflammation inflammatory state influence molecular molecular. morbidity and mortality obese pathophysiological Patient predictor pro-inflammatory reported resulting SARS-CoV2 systemic damage target type 2 diabete virus [DOI] 10.1016/j.bbadis.2022.166559 PMC 바로가기
A variant NS1 protein from H5N2 avian influenza virus suppresses PKR activation and promotes replication and virulence in mammalsArticle Published on 2022-12-012023-06-14 Journal: Emerging Microbes & Infections [Category] Fulltext, 조류인플루엔자, [키워드] cytokine Highly pathogenic avian influenza viruses host range. NS1 NS3 PKR [DOI] 10.1080/22221751.2022.2114853 PMC 바로가기